Monitoring Cyclosporine Absorption: A Step Beyond Therapeutic Drug Monitoring

monitoring cyclosporine absorption: a step beyond therapeutic drug monitoring

Monitoring Cyclosporine Absorption: A Step Beyond Therapeutic Drug Monitoring

which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. In their recent large, retrospective, cross-sectional study with 7702 renal-transplant patients, Einollahi et al. showed that cyclosporine (CsA) absorption (CA) steadily increases over 3 years post transplant (1). They also indicated that despite the day-today and inter-in...

A Review on Therapeutic Drug Monitoring of Immunosuppressant Drugs

Immunosuppressants require therapeutic drug monitoring because of their narrow therapeutic index and significant inter-individual variability in blood concentrations. This variability can be because of factors like drug-nutrient interactions, drug-disease interactions, renal-insufficiency, inflammation and infection, gender, age, polymorphism and liver mass. Drug monitoring is widely practiced ...

therapeutic drug monitoring

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Therapeutic Monitoring of Cyclosporine*f

Therapeutic monitoring of immunosuppressive therapy with cyclosporine is a critical requirement because of intraand interpatient variability of drug absorption, narrow therapeutic window and drug induced nephrotox­ icity. The most widely used procedure involves measuring trough concen­ trations of cyclosporine (CsA) parent drug in whole blood using a specific monoclonal immunoassay. Trough conc...